Colloquium: Mathematical and experimental models of cell invasion with fluorescent cell cycle indicators

Seminar/Forum

Colloquium: Mathematical and experimental models of cell invasion with fluorescent cell cycle indicators

Russell Love
Peter Hall Building

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More information

nathan.ross@unimelb.edu.au

Fluorescent cell cycle indicators, such as FUCCI, allow us to visualise the cell cycle in individual cells. FUCCI reveals real-time information about cell cycle dynamics in individual cells, and can be used to explore how the cell cycle relates to the location of cells, local cell density, and different microenvironments. In this talk we will describe how FUCCI technology can be incorporated into continuum and discrete models of cell invasion. Using experimental data from scratch assays with FUCCI-transduced melanoma cells, we show how mathematical models can be used to predict key features of the experiments. Some analysis of travelling wave solutions of the models will also be presented.

Presenter

  • Professor Matthew Simpson
    Professor Matthew Simpson, Queensland University of Technology