Sophie G Zaloumis, J. Whyte, Joel Tarning, Sanjeev Krishna, J. McCaw, P. Cao, Michael T White, Saber Dini, Freya JI Fowkes, Richard J Maude, Peter Kremsner, Arjen Dondorp, Ric N Price, Julie A Simpson. Development and validation of an in silico decision-tool to guide optimisation of intravenous artesunate dosing regimens for severe falciparum malaria patients.. Antimicrobial agents and chemotherapy, 65, 2021. doi: 10.1128/AAC.02346-20.
Ke Li, J. McCaw, P. Cao. Modelling within-host macrophage dynamics in influenza virus infection.. Journal of Theoretical Biology, 508, 110492 (10pp), 2020. doi: 10.1016/j.jtbi.2020.110492.
David S Khoury, P. Cao, Sophie G Zaloumis, Miles P Davenport, Interdisciplinary Approaches to Malaria Consortium. Artemisinin Resistance and the Unique Selection Pressure of a Short-acting Antimalarial.. Trends in parasitology, 36, 884-887, 2020. doi: 10.1016/j.pt.2020.07.004.
P. Cao, Katharine A Collins, Sophie Zaloumis, Thanaporn Wattanakul, Joel Tarning, Julie A Simpson, James McCarthy, J. McCaw. Modeling the dynamics of Plasmodium falciparum gametocytes in humans during malaria infection.. eLife, 8, e49058 (21pp), 2019. doi: 10.7554/eLife.49058.
P. Cao, Katharine Collins, Sophie Zaloumis, Thanaporn Wattanakul, Joel Tarning, Julie Simpson, James McCarthy, J. McCaw. Modelling the population dynamics of Plasmodium falciparum gametocytes in humans during malaria infection. 641472, Cold Spring Harbor Laboratory, 2019. doi: 10.1101/641472.
Ivo Siekmann, P. Cao, James Sneyd, E. Crampin. Data-Driven Modelling of the Inositol Trisphosphate Receptor ( $$ ext {IP}_3 ext {R}$$ ) and its Role in Calcium-Induced Calcium Release (CICR). 39-68, Springer International Publishing, 2019. doi: 10.1007/978-3-030-00817-8_2.
Z. Wang, L. Zhu, T. Nguyen, Yanmin Wan, Sneha Sant, Sergio M Quiñones-Parra, Jeremy Chase Crawford, Auda A Eltahla, Simone Rizzetto, Rowena A Bull, Chenli Qiu, Marios Koutsakos, E Bridie Clemens, Liyen Loh, Tianyue Chen, N. LIU, P. Cao, Yanqin Ren, Lukasz Kedzierski, Tom Kotsimbos, J. McCaw, Nicole L La Gruta, Stephen J Turner, Allen C Cheng, Fabio Luciani, X. Zhang, Peter C Doherty, Paul G Thomas, J. Xu, Katherine Kedzierska. Clonally diverse CD38+HLA-DR+CD8+T cells persist during fatal H7N9 disease.. Nat Commun, 9, 824 (12pp), 2018. doi: 10.1038/s41467-018-03243-7.
Tan N Doan, P. Cao, Theophilus I Emeto, J. McCaw, Emma S McBryde. Predicting the Outcomes of New Short-Course Regimens for Multi-Drug Resistant Tuberculosis Using Intrahost and Pharmacokinetic-Pharmacodynamic Modelling.. Antimicrobial agents and chemotherapy, aac.01487-aac.01418, 2018. doi: 10.1128/AAC.01487-18.
S Dini, S Zaloumis, P. Cao, RN Price, FJI Fowkes, RW Van Der Pluijm, J. McCaw, JA Simpson. Investigating the efficacy of triple artemisinin-based combination therapies (TACTs) for treating Plasmodium falciparum malaria patients using mathematical modelling.. Antimicrobial agents and chemotherapy, 62, e01068-e01018, 2018. doi: 10.1128/AAC.01068-18.
SG Zaloumis, P. Cao, S Dini, MP Davenport, D Cromer, DS Khoury, FJI Fowkes, J. McCaw, JA Simpson. In silico investigation of the decline in clinical efficacy of artemisinin combination therapies due to increasing artemisinin and partner drug resistance.. Antimicrobial agents and chemotherapy, 62, aac.01292-aac.01218, 2018. doi: 10.1128/AAC.01292-18.
P. Cao, Nectarios Klonis, Sophie Zaloumis, David S Khoury, Deborah Cromer, Miles P Davenport, Leann Tilley, Julie A Simpson, J. McCaw. A mechanistic model quantifies artemisinin-induced parasite growth retardation in blood-stage Plasmodium falciparum infection. Journal of Theoretical Biology, 430, 117-127, 2017. doi: 10.1016/j.jtbi.2017.07.017.
P. Cao, Nectarios Klonis, Sophie Zaloumis, Con Dogovski, Stanley C Xie, Sompob Saralamba, Lisa J White, Freya JI Fowkes, Leann Tilley, Julie A Simpson, J. McCaw. A Dynamic Stress Model Explains the Delayed Drug Effect in Artemisinin Treatment of Plasmodium falciparum. Antimicrobial Agents and Chemotherapy, 61, AAC.00618-17 (16pp), 2017. doi: 10.1128/AAC.00618-17.
P. Cao, J. McCaw. The Mechanisms for Within-Host Influenza Virus Control Affect Model-Based Assessment and Prediction of Antiviral Treatment. Viruses-Basel, 9, 197 (20pp), 2017. doi: 10.3390/v9080197.
Tuo Yang, Stanley C Xie, P. Cao, Carlo Giannangelo, J. McCaw, Darren J Creek, Susan A Charman, Nectarios Klonis, Leann Tilley. Physiologically Relevant Exposure to Synthetic Ozonoide Antimalarials Kills K13 Wildtype and Mutant Plasmodium Falciparum More Effectively than DIHYDROARTEMISININ. American Journal of Tropical Medicine and Hygiene, 95, 78 (1pp), 2017.
Ada WC Yan, P. Cao, Jane M Heffernan, Jodie McVernon, Kylie M Quinn, Nicole L La Gruta, Karen L Laurie, J. McCaw. Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host. Journal of Theoretical Biology, 413, 34-49, 2017. doi: 10.1016/j.jtbi.2016.11.008.
P. Cao, Martin Falcke, James Sneyd. Mapping Interpuff Interval Distribution to the Properties of Inositol Trisphosphate Receptors. Biophysical Journal, 112, 2138-2146, 2017. doi: 10.1016/j.bpj.2017.03.019.
A. Yan, P. Cao, Jane M Heffernan, Jodie McVernon, Kylie M Quinn, Nicole L La Gruta, Karen L Laurie, J. McCaw. Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host (vol 413, pg 34, 2017). Journal of Theoretical Biology, 419, 394 (1pp), 2017. doi: 10.1016/j.jtbi.2017.03.015.
Ada WC Yan, P. Cao, J. McCaw. On the extinction probability in models of within-host infection: the role of latency and immunity. Journal of Mathematical Biology, 73, 787-813, 2016. doi: 10.1007/s00285-015-0961-5.
Tuo Yang, Stanley C Xie, P. Cao, Carlo Giannangelo, J. McCaw, Darren J Creek, Susan A Charman, Nectarios Klonis, Leann Tilley. Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains. Antimicrobial Agents and Chemotherapy, 60, 4501-4510, 2016. doi: 10.1128/AAC.00574-16.
P. Cao, Zhongfang Wang, Ada WC Yan, Jodie McVernon, Jianqing Xu, Jane M Heffernan, Katherine Kedzierska, J. McCaw. On the Role of CD8(+) T Cells in Determining Recovery Time from Influenza Virus Infection. Frontiers in Immunology, 7, 611 (13pp), 2016. doi: 10.3389/fimmu.2016.00611.
K Laurie, T Guarnaccia, L Carolan, W Horman, A. Yan, M Aban, S Petrie, P. Cao, J Heffernan, J McVernon, J Mosse, A Kelso, J. McCaw, I Barr. The time-interval between infections and viral hierarchies are determinants of viral interference following influenza virus infection in a ferret model. European Journal of Immunology, 46, 685-686, 2016.
Karen L Laurie, Teagan A Guarnaccia, Louise A Carolan, Ada WC Yan, Malet Aban, Stephen Petrie, P. Cao, Jane M Heffernan, Jodie McVernon, Jennifer Mosse, Anne Kelso, James M Mccaw, J. McCaw, Ian G Barr, JM McCaw. Interval Between Infections and Viral Hierarchy Are Determinants of Viral Interference Following Influenza Virus Infection in a Ferret Model. Journal of Infectious Diseases, 212, 1701-1710, 2015. doi: 10.1093/infdis/jiv260.
P. Cao, Ada WC Yan, Jane M Heffernan, Stephen Petrie, Robert G Moss, Louise A Carolan, Teagan A Guarnaccia, Anne Kelso, Ian G Barr, Jodie McVernon, Karen L Laurie, James M McCaw, J. McCaw. Innate Immunity and the Inter-exposure Interval Determine the Dynamics of Secondary Influenza Virus Infection and Explain Observed Viral Hierarchies. PLoS Computational Biology, 11, e1004334 (28pp), 2015. doi: 10.1371/journal.pcbi.1004334.
P. Cao, Xiahui Tan, Graham Donovan, Michael J Sanderson, James Sneyd. A Deterministic Model Predicts the Properties of Stochastic Calcium Oscillations in Airway Smooth Muscle Cells. PLoS Computational Biology, 10, e1003783, 2014. doi: 10.1371/journal.pcbi.1003783.
P. Cao, Graham Donovan, Martin Falcke, James Sneyd. A Stochastic Model of Calcium Puffs Based on Single-Channel Data. Biophysical Journal, 105, 1133-1142, 2013. doi: 10.1016/j.bpj.2013.07.034.